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Peyronie's Disease
Peyronie's Disease

What Is Peyronie's Disease?

Peyronie's disease occurs when scar tissue creates a curvature in the penis. This scar tissue, also known as plaques, can lead to curvature or deformity of the penis during an erection, making sexual intercourse difficult or painful.


The symptoms of Peyronie's disease can vary from mild to severe and can develop gradually or appear suddenly. Common symptoms include:

  1. Penile curvature: The most apparent symptom of Peyronie's disease is the development of an abnormal curvature of the penis during an erection. The curvature can be upward, downward, or sideways, and its severity can vary among individuals.
  2. Pain or discomfort: Some men may experience pain or discomfort in the affected area, particularly during an erection or sexual activity. The pain can range from a small amount of discomfort to intense pain. The pain may interfere with sexual intercourse.
  3. Erectile dysfunction: Peyronie's disease can contribute to difficulties in achieving or maintaining an erection, leading to erectile dysfunction.
  4. Penile indentation or narrowing: In some cases, the plaques can cause areas of indentation or narrowing along the shaft of the penis, resulting in an hourglass-like appearance.

Causes of Peyronie’s Disease

The exact cause of Peyronie's disease remains unknown. However, several factors may contribute to its development:

  1. Trauma or injury: A history of trauma or injury to the penis, such as bending or hitting, is a potential cause of Peyronie's disease. However, not all men with the condition have a history of penile trauma.
  2. Genetic predisposition: Some evidence suggests that there can be a genetic predisposition to Peyronie's disease, as it can run in families.
  3. Connective tissue disorders: Certain connective tissue disorders, like Dupuytren's contracture, may be associated with an increased risk of developing Peyronie's disease.


To diagnose this disease, a urologist will perform a thorough evaluation, including:

  1. Medical history review: The urologist will ask about symptoms, medical history, and any history of penile trauma or injury.
  2. Physical examination: The physician will examine the penis for plaques, curvature, or other abnormalities.
  3. Imaging tests: Ultrasound imaging may be used to look more closely at the plaques and assess the degree of penile curvature.

Treatment of Peyronie’s Disease

Treatment options for Peyronie's disease aim to alleviate symptoms, improve sexual function, and correct penile curvature. Treatment choice depends on the severity of symptoms, the degree of curvature, and individual preferences. Some treatment options include:

  1. Watchful waiting: In mild cases where the curvature is not causing significant discomfort or interference with sexual function, the urologist may recommend monitoring the condition without active treatment.
  2. Medications: Oral medications, such as vitamin E, potassium aminobenzoate, or pentoxifylline, may be prescribed to manage pain and reduce plaque formation.
  3. Xiaflex injections: Xiaflex is an FDA-approved medication specifically designed to treat Peyronie's disease. It is administered through a series of injections directly into the penile plaque. Xiaflex contains an enzyme that breaks down the collagen buildup within the plaques, thereby reducing penile curvature. The treatment typically involves two injection sessions spaced several days apart.
  4. Penile traction therapy: A mechanical device gently stretches the penis, aiming to reduce curvature over time. Traction therapy is typically done in combination with other treatments.
  5. Surgical intervention: In severe cases of Peyronie's disease, surgical correction may be necessary. Surgical options include plaque removal, grafting procedures, or penile prosthesis implantation.

It’s important to note that topical medications, like Verapamil, are ineffective in treating Peyronie’s disease.


Like any medical intervention, treatments for Peyronie's disease carry certain risks and potential complications. These may include:

  1. Infection: Surgical procedures carry a risk of infection, which can be treated with antibiotics.
  2. Erectile dysfunction: Surgical interventions can occasionally lead to erectile dysfunction or worsening of pre-existing erectile dysfunction.
  3. Penile shortening: In some cases, surgical procedures may result in penile shortening, although measures are taken to minimize this risk.
  4. Complications specific to Xiaflex: Xiaflex treatment may cause temporary swelling, bruising, or penile pain. There is also a risk of penile fracture during the treatment procedure.

When to See a Doctor for Penile Curvature

Peyronie's disease is a condition that can significantly impact a man's sexual function and quality of life. With early diagnosis and appropriate treatment, many individuals with Peyronie's disease can experience symptom relief and improved sexual function.

If you suspect you may have Peyronie's disease, it’s crucial to consult with a qualified urologist. They can provide an accurate diagnosis and recommend the most suitable treatment options for your specific case.

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